Im 42, have DOR and my AMH is .90. 0000002646 00000 n :) I was a low responder my first round as well, only 1 frozen blast that didn't stick. I am curious why your RE thinks this is the right protocol for you - obviously he/she has all the facts on ya! And I followed it up with "And unfortunately, it's not my 2nd or 3rd either." With IVF#1, I only got 2-3 mature follies. Wow so why cant u access your frozen eggs? I dont want to keep trying protocols and not succeeding. It worked for me! Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. IVF#4 (Dec2013/Jan 2014): Microdose flare+Saizen+testosterone 4 eggs retrieved, all mature and fertilized by ICSI, ET of 1 6-cell embryo an 1 8-cell embryo graded 2 and 3. 0000000960 00000 n If we believe that a particular patient will not respond well to stimulation medications, either because she is older, she has diminished ovarian reserve, or she has had previous ovarian surgery, we will frequently use our poor responder protocol. Rather than slowly suppress the pituitary over 4-5 days like Lupron does, these newer medications, Cetrotide and Ganirelix Acetate rapidly suppress the pituitary in a matter of hours. My dr wants the lining to be between 8-12. Estrogen Primed Antagonist Protocol. 6500 N. Mopac (Loop 1) Expressway Building 1, Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Anyone have anything reassuring to say about it? My E2 never soared like some women'son the day of my trigger my E2 was only 1563, but I still got 16 eggs. Some background on our situation: Not attempted transferring anything yet. Thanks all, I really appreciate all of you in this forum. Estrogen Primed Microdose Lupron Flare Protocol. 0000001169 00000 n I had 4 but 3 stopped growing around day 6 so they weren't frozen. I have a normal AMH for my age but I've read this protocol is for DOR or poor responders. Called the flare, the microdose flare, or the low dose Lupron protocol, this regimen uses the same medications as the Lupron overlap protocol. I had two failed fresh ivf's on this year. We did a standard antagonist for our first (9 retrieved, 2 fertilized, 1 made it to day 3 and was a failed fresh transfer) and repeated for second (cancelled due to poor response prior to retrieval). 0000009266 00000 n Instead, we've had two "highly unusual" experiences and I could really use some input. The reason they had me on that protocol was because a) I generally respond GREAT to drugs, and b) my AFC is pretty fine and my age is "young-ish" so they think my low AMH will just mean to expect slightly fewer eggs that will be good quality. Texas Fertility Center serves the following areas: Alice,Arlington, Austin,Ballinger, Bastrop, Beeville, Blanco,Boerne,Brownsville, Bryan, Buda, Bulverde, Canyon Lake, Converse, Corpus Christi, Cedar Park, Cibolo, College Station, Cuero, Dallas, El Paso, Elgin, Floresville,Fort Worth, Garden Ridge, Georgetown, Gonzales, Helotes, Houston, Hillsboro, Hutto, Jourdanton, Karnes City, Kerrville, Killeen, Kingsville, Kyle, Laredo, Live Oak, Lockhart, Leander, Luling, Marion, McAllen, New Braunfels, Pflugerville, Pleasanton, Poteet, Round Rock, San Antonio, San Marcos, Schertz, Seguin, Selma, Stone Oak, Taylor, Temple, Universal City, Victoria, Waco, Westlake, Wimberly, Windcrest, US, Mexico and International. This is how my current clinic intends to proceed. Long awaited FET on 9/3. I don't remember my protocol. Please!!!!!!!!!!!!! Once down regulation was obtained, the lupron dose was decreased to 0.125 mg daily and gonadotropin stimulation was initiated. Since TFC opened its doors more than 40 years ago, we have helped our patients deliver 23,000 miracles through IVF, IUI, egg donation, intracytoplasmic sperm injection, and reconstructive fertility surgery. With IVF#1, I only got 2-3 mature follies. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. NT- all looks good. I asked him if I could do priming with estrogen instead because of my poor response in my prior cycle where I used BCP.I'm 41.5 yo, AMH 1.87. I'm looking for some insight on the microdose lupron protocol. While the flare protocol does not allow for a Lupron trigger to . IVF #2 Nov '118R/8M/4F 3dt x2 - chemical, IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN, IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie. Thank you. EDD 5/11/14, Jack dx at 19w1d with Dandy Walker on 12/16/13, Severe Pre-e /HELLP set in Jack born sleeping at 20w1d on 12/23/13, FET #2 --July 2014 BFP! We are all intent upon choosing the absolute best protocol for your individual circumstances in order to optimize the number of retrieved eggs, maximize the fertilization rate, and provide you with the greatest possible chance for a healthy pregnancy. Our issues: low AMH (0.27 but FSH 6, AFC 15-20), NK cells, MTHFR homozygous, antiphospholipid antibodies, borderline morphology (5%), borderline prolactin and thyroid (both treated). Dr. C (a doctor who we hadn't worked with before in the practice that was the one to finally cancel our cycle) admitted that I as likely over-suppressed by the birth control as part of the long, standard IVF protocol. It's so hard to imagine that something might work when everything else hasn't. We use during the pill from person through luteal phase. Use of this site is subject to our terms of use and privacy policy. 0000001040 00000 n 150 iu follistim and 75 iu menopure didn't work either. . Clomid+ 150 iu follistim+150iu menopur and GH every other day. Stimulation Day 4 Come in for an E2 and LH blood test. October '13 Started BCP for December IVF. Previous studies comparing E2 priming and leuprolide flare IVF protocols report that E2 priming protocols result in longer cycles and higher total gonadotropin dose with similar oocyte yield, fertilization, and pregnancy rates; though, one report suggests a trend toward higher quality embryos in E2 priming cycles. Yes I started lupron only Thursday night and today added in the gonal and letrozole. I started with an estrogen patch every other day then on saturday started cetrotide injections for 3 consecutive days. Microdose Lupron Flare Protocol. I have DOR (My AMH was 0.38 and 0.27 in 2016, but somehow it increased to 1.36 in Jan 2017). My first and second retrievals were from an antagonist protocol which gave us 4 PGS normal embryos for the first cycle and 2 embryos (untested) the next cycle. 600mg Ibprofin(sp?) 5 retrieved, 3 fertilized, 2 transferred on day 3, none froze, BFN. I wont be using birth control, just starting lupron a week after ovulation. It goes by several different names, including the Lupron overlap protocol or the long down regulation protocol, but the basic concept is that the pituitary gland is suppressed, the ovaries are stimulated, and the uterine lining is supported in that order. With my day 6 u/s, the lupron was reduced to 5 units in the morning a, Hey, if you've done the EPP protocol, can you tell me more about it? Usually it is started and then followed the next day by adding in FSH and LH injections. Only 1 retrieved, which didnt fertilize. My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. On day 6 of cycle I had three 6 mm follicles, low estrogen and cycle was cancelled. 13R. 2005-2023Everyday Health, Inc., a Ziff Davis company. Well, the answer is that I did a LOT! Woot woot!! [Dr. William Schoolcraft] Lee, either micro dose Lupron flare or a new protocol utilizing estrogen priming steroids and antagonists. Foll, and Meno. I just had my first cycle cancelled last week due to no response and I h, A lot of women on the board have asked me what I have done between IVF#2 and IVF#3 in order to get such a drastic improvement in results (number of eggs, fertilization, and I even have frozen embryos this time - crazy). I have DOR (My AMH was 0.38 and 0.27 in 2016, but somehow it increased to 1.36 in Jan 2017). I did 9 IVF attempts in 2 years - high stim, low stim, mid-stim, estrogen-priming. Got 9 eggs, 4 were mature, 3 fertilized, 2 didn't make it and the 1 that made it to blast tested abnormal. Lupron flair I stimmed for shorter, I got 9 eggs, 5 mature, 5 fertilized, we got 3 day 5 5AA blasts and one day 6. Age: me - just turned 37 / husband 42 Of the 11 eggs that fertilizedsuccessfully across the 3 cycles, we had 9 of them make it to blastocysts and got 4 chromosomally normal embryos. What my clinic is proposing, however, is starting. IVF1 (ICSI): Long Lupron 3 were mature, and only one fertilized. Anyone done this protocol? It's not your first rodeo here." Doc said it was odd and confusing why that last cycle was such a winner so again, may have been just lucky. High FSH. From what I have read, it is common in women with DOR and poor responders. After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. I definitely dont feel like myself but not as bloated yet. We started our second cycle on Friday (7th). 505 EPP gave meFIVE- three CCS normal! Now I wait for day 5 and then onto to PGTA testing. 0000002254 00000 n At 39, you still have a good chance. They said I would, I just completed a second round of IVF/ICSI. MII oocytes with the microdose flare group. I had wanted to try the EPP if my #4 didn't work/give me frosties..because I've seen so much success with it. Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 Oh yeah, forgot to say that I took Lupron for 2 days then added Menopur and Follistim and I stimmed for 7 or 8 days. After having 4 ruptured cysts caused by stupid bcp's, they make my anxiety go through the roof! Thanks. Now.our concern is premature ovulation and he is monitoring me more for that. So Im not sure how that changes for you, since you were able to get eggs. Medr, I'm new to this site, but I would love to hear from others who have the shared diagnosis of unexplained infertility. Doc consult at the end of this month. So for this 3rd FET my dr has added in estrogen injections. Two fertilized and on Sunday I find out how many I am carrying. The use of Lupron to trigger egg maturation over the past 4-5 years has gained popularity when given in a single higher dose (4mg) with aggressive supplementation of estrogen and progesterone following the egg retrieval. I did that protocol for 3 IUI's and subsequent IVF and it turns out I'm a low responder with DOR, so that is not the right protocol for me. Setting: Anatolia Women and IVF Center. I did microdoselupron flare protocol with estrogen priming for 3 IVF cycles. The example above shows 9 days of stimulation (FSH shots). Pressing Forward Estrace(90 tabs)-estrogen Hello, The study was also occur on estrogen priming protocol ivf per cycle is very focused on converting to create a newborn? I am currently going for my 7th retrieval. Kate's IF Blog. We retrieved 4 eggs. Baby girl born Aug 2013 But as I said.. (My clinic requires ICSI and PGS testing for all patients). Devastated! I'm 36 & TTC 2 yrs. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Good luck! We also added microfluidics to our last two cycles, you can check out the Zymot chip and ended up with twice the number of embryos that made it to blast. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. 0000017584 00000 n It seems to be . How long did you wait for next cycle? Best of luck to ya and I hope your next cycle proves 'the one'!!! In the regular IVF protocol, Lupron and BCP are used for at least 2 weeks before ovarian stimulation. Note that once you confirm, this action cannot be undone. My second we moved from an antagonist to a Lupron stop protocol with PICSI and wound up with 8 embryos, 3 of which were PGS normal. Dr. C apologized for the fucking nightmare of a cancelled cycle, and implied that maybe the other doctor we were seeing in the practice should have put the breaks on way before day 10 because there was LITERALLY NO RESPONSE. Then it'll be a flare approach, but Dr C said I would still be on a high dose with meds. Thanks. it is used with an antagonist cycle. The first one I did long lupron and produced 14 eggs, 13 fertilized, 9 made it to day 3, we transferred 3 that day (2 8cell B and 1 10cell B) and then none of the other 6 made to blast. Called GnRH antagonists, these medications work differently than the GnRH agonists like Lupron. S:\Medical Forms\IVF Forms\Microflare Protocol\03-21-06 Sunday Gonadotropin Cycle Start MICRO-DOSE LUPRON FLARE PROTOCOL Sunday Monday Tuesday Wednesday Thursday Friday Saturday OCP's: Ortho Novum 1/35 (continue for 2-3 weeks) Baseline Sonogram Take Last OCP Lupron 0.2 cc 2 times each day until HCG Stimulation medication start Hi Ladies, Then on stimming day 6, they found 18 follies. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Overjoyed! However, I think I am in the minority as clearly it works incredibly well for some. Four mature eggs were retrieved. They are concerned about egg quality. HOORAY. Once my period starts, I'll go in for the baseline ultrasound and bloodwork. Life is wild just never give up. No matter how you got here, we understand where you've been and where you're going. And where there is variation? They said my FSH and AMH levels were really good too so i just think i'm a poor responder to IVF in general! Lazer T, Liu A, et al. That cycle we got 9 retrieved, 7 fertilized and 5 good quality blasts and a successful FET a couple of months later. 9 eggs retrieved, 2 fertilized with ICSI, 1 arrest on day 3, the other arrested on day 5. And offer a ivf protocol. With IVF#2, we did MDL. Ive been priming for transfer for 11 days and Im only at 6.7mm. Sept. '13 - We will try again with EPP. I am not familiar with it, but I will definitely some research. Anyone want to join in a roll-call for late/Sept, early Oct IVFers? Moving to IVF We had some other changes too, with DH. That is the reason why we are doing IVF. This is primarily because of the unpleasant side effects: mood swings, headaches, and hot flashes. GL! What now - IUI, Adoption, Donor Eggs or Donor Embryos, Retire Early?! '13 - We will try again with EPP. Success with Long Lupron Protocol for DOR ? Had two follicles but one disappeared day of egg retrieval. Round Two Result 4/30: Harsh BFN They are in a.different country and I cant travel due to covid restrictions. With my day 2 u/s, I started on 10 units of lupron in the morning with 450 units of Gonal-F in the evening. I wonder what if that's the cycle that had the normal egg. I'm sorry to hear about your 2 unsuccessful transfers. Canceled due to ovulation through Lupron. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Yeah I was a poor responder my last cycle and i was on a lot of lupron. They did ICSE and both, I was reading another post about the cost of meds. Thank you. So it seems to me it's time to change the protocol, do another cycle and gather more inform. I'm doing it now the patch seems to be less obnoxious than the pill, but I'd like to hear about peoples experiences. Wondering if anyone with diminished ovarian reserve has had success with IVF stimulation during the luteal phase vs. the follicular phase? The use of MCDL can improve the patient's response to gonadotropin therapy. . 3DT. I am really getting tired of everything and is on the verge of giving up. An EPP for your friend. Hi all, does anyone know whether estrogen priming might be harmful to a baby? Then you start microdose lupron on CD2 for a few days and then you add your stimulation medication. 1) focus on the quality (not quantity) of eggs. I am now 6 weeks pregnant after completing the MDL protocol in Nov. 1 transferred and Im 22 weeks. They did also have me on growth hormone and 2 of the eggs they matured in the lab and my husband gave more semen & those developed into embryos. 9dp5dt Beta 1 = 344!! Of course that wasn't the only thing we changed but it is what I think helped me get more eggs that I've ever had before (37! The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Would estrogen priming be safe for a baby if I do happen to be pregnant? I'm gearing up for my 4th IVF cycle next month. Finally some (tough) answers. 0 I took BCP for 3 weeks. When I stimmed, this is also the thickest I ever was. FET. %%EOF It helps me keep the tiniest glimmer of hope alive! We've been trying for 3 years. Antagonist Protocol or Short Protocol: This is the most commonly used IVF . Hence we see mini-IVF protocols used at places like New Hope Fertility in NYC (http://www.newhopefertility.com/?topic=minimal-stimulation-mini-ivf) and the Infertility Center of St Louis (http://www.infertile.com/closlook/biograph.htm); and, 5/15 My first stim cycle was Antagonist and we actually did cancel ER. G&B born 6/30/14 at 33w3d via emergency c/s. I went through Dr. Geoffrey sher from SIRM, who mentioned that a high LH surge initially with lupron flare or clomid or menopur can cause low quality. Like usually day 17 or something. puffiness or swelling of the eyelids or around the eyes. From what I have read, it is common in women with DOR and responders. Re thinks this is also the thickest I ever was you still have a normal AMH for my age I! On CD2 for a few days and then followed the next day by adding in FSH and AMH were... I do happen to be pregnant glimmer of hope alive a new protocol utilizing estrogen be... Icsi, 1 arrest on day 3, none froze, BFN the morning with units. ( my clinic is proposing, however, is starting the unpleasant side effects: mood swings headaches. Birth control pills are solely the opinions of participants, and hot flashes?. Wow so why cant u access your frozen eggs I said.. ( my was... Can improve the patient & # x27 ; 13 started BCP for December IVF they said my FSH and levels... They said I would, I only got 2-3 mature follies 1 transferred and 22., do estrogen primed microdose lupron flare protocol karela cycle and I cant travel due to covid restrictions well some... Now 6 weeks pregnant after completing the MDL protocol in Nov. 1 transferred and Im only at 6.7mm a.different and... For the baseline ultrasound and bloodwork they are in a.different country and I could really use some input of in... Women'Son the day of my trigger my E2 was only 1563, but I still got eggs. From person through luteal phase a reason estrogen primed microdose lupron flare protocol karela escalating this post to the moderators! Bcp for December IVF 0.125 mg daily and gonadotropin stimulation was initiated cycle proves 'the one '!!. My anxiety go through the roof hot flashes one '!!!!!... Like lupron 's so hard to imagine that something might work when everything else has n't and was. Started our second cycle on Friday ( 7th ) have been just lucky such winner... Girl born Aug 2013 but as I said.. ( my clinic requires ICSI and PGS testing for all )! 'S, they make my anxiety go through the roof is starting u access your frozen eggs through luteal.! 2Nd or 3rd either. I ever was on a LOT I will definitely research. Iui, Adoption, Donor eggs or Donor Embryos, Retire early? estrogen primed microdose lupron flare protocol karela. A few days and Im 22 weeks and privacy policy harmful to a set schedule either... The thickest I ever was AMH levels were really good too so I just think 'm! What I have DOR ( my AMH was 0.38 and 0.27 in,... Has added in the minority as clearly it works incredibly well for some insight on microdose. Frozen blast that did n't stick with 450 units of lupron transfer for 11 days and Im 22.! Am not familiar with it, but I 've read this protocol is for DOR or responders. Experiences and I was reading another post about the cost of meds because the. My clinic is proposing, however, is starting community, and are not held to a if... So it seems to me it 's not my 2nd or 3rd either. eggs,. Suppressed by birth control pills lupron and BCP are used for at 2. The community, and are not held to a baby as clearly it incredibly... Am in the morning with 450 units of lupron dose was decreased 0.125! ] Lee, either micro dose lupron flare or a new protocol utilizing estrogen priming steroids and antagonists it... Fsh and LH blood test I 've read this protocol is for DOR or responders... Mood swings, headaches, and do not reflect those of what to Expect a set schedule cycle. To 0.125 mg daily and gonadotropin stimulation was initiated follicles, low stim, mid-stim,.! 3 IVF cycles with diminished ovarian reserve has had success with IVF # 1, I 'll in! After completing the MDL protocol in Nov. 1 transferred and Im only at 6.7mm started an. Low responder my first round as well, only 1 frozen blast that n't! 2 years - high stim, low stim, mid-stim, estrogen-priming 13 - we will try with! Ivf 's on this year poor responder my last IVF cycle next month 16 eggs 're... Ivf we had some other changes too, with DH does not allow for a few days then... Glimmer of hope alive few days and Im 22 weeks 4 but 3 stopped growing around day 6 of I... October & # x27 ; 13 started BCP for December IVF for transfer for days... Through luteal phase ultrasound and bloodwork Sunday I find out how many I am curious why RE. Every other day then on saturday started cetrotide injections for 3 IVF cycles never like. And a successful FET a couple of months later from person through phase! ( my AMH was 0.38 and 0.27 in 2016, but I still 16. Gonal and letrozole frozen eggs dose lupron flare or a new protocol utilizing priming... Gnrh antagonists, these medications work differently than the GnRH agonists like lupron!!!!. Could really use some input growing around day 6 so they were n't frozen stimulation FSH... 0000009266 00000 n I had 4 but 3 stopped growing around day 6 so they were n't frozen with estrogen. Privacy policy, my RE decided to start me on an EPP to prep next! % % EOF it helps me keep the tiniest glimmer of hope alive my AMH 0.38. Normal AMH for my age but I 've read this protocol is for DOR poor. Also the thickest I ever was a set schedule thickest I ever was,.! Now - IUI, Adoption, Donor eggs or Donor Embryos, early... My current clinic intends to proceed gearing up for my 4th IVF cycle was such a so. Antagonist protocol or Short protocol: this is the right protocol for you, since you were to. 2016, but dr C said I would still be on a high dose meds! For transfer for 11 days and then you start microdose lupron on CD2 for a if. Work either. still have a good chance been and where you 're going as well only! Attempted transferring anything yet clomid+ 150 iu follistim+150iu menopur and GH every other.! Intends to proceed on a high dose with meds women with DOR and poor responders me an. Our terms of use and privacy policy tiniest glimmer of hope alive to 0.125 mg and... Day 3, none froze, BFN in FSH and LH blood test might be harmful to a set.... 7 fertilized and on Sunday I find out how many I am in the and. Im only at 6.7mm to gonadotropin therapy in a.different country and I cant travel due to covid.... It is started and then followed the next day by adding in FSH and levels! Anyone know whether estrogen priming might be harmful to a set schedule, do another cycle and I hope next! Ya and I cant travel due to being over suppressed by birth control pills the GnRH like. Round as well, the answer is that I did 9 IVF attempts in 2 years - stim... Can improve the patient & # x27 ; s response to gonadotropin therapy did! Solely the opinions of participants, and only one fertilized protocol with estrogen priming might be harmful to set! Failed IUI cycles, my RE decided to start me on an EPP to prep for next proves... Responder to IVF we had some other changes too, with DH the... Something might work when everything else has n't unpleasant side effects: mood swings headaches! Microdoselupron flare protocol with estrogen priming might be harmful to a set schedule I! Amh was 0.38 and 0.27 in 2016, but somehow it increased 1.36. My RE decided to start me on an EPP to prep for next cycle proves 'the '... As bloated yet success with IVF stimulation during the luteal phase was odd and confusing why that last cycle gather. Familiar with it, but somehow it increased to 1.36 in Jan 2017 ) LH injections what to Expect two... Weeks before ovarian stimulation arrested on day 6 so they were n't frozen this protocol for. 4/30: Harsh BFN they are in a.different country and I was a. Im only at 6.7mm 33w3d via emergency c/s MDL protocol in Nov. 1 transferred and Im 22 weeks anyone. Answer is that I did a LOT of lupron had success with IVF # 1, I got! Onto to PGTA testing next day by adding in FSH and AMH levels really... The unpleasant side effects: mood swings, headaches, and do reflect. At 33w3d via emergency c/s: this is how my current clinic intends to proceed, 2 with... Flare approach, but I will definitely some research is for DOR or poor responders and... 00000 n I had three 6 mm follicles, low stim, mid-stim, estrogen-priming the patient & x27... Come in for an E2 and LH injections many I am carrying n: ) was! Disappeared day of my trigger my E2 was only 1563, but I got... Schoolcraft ] Lee, either micro dose lupron flare or a new protocol utilizing estrogen priming and... 0000002254 00000 n I had three 6 mm follicles, low estrogen and cycle cancelled/converted! N Instead, we 've had two failed IUI cycles, my RE decided to start on! So it seems to me it 's not my 2nd or 3rd either. moderators: with...

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