A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20C; on spraying or dispersing, however, much faster. The analysis and recommendations made in this blog post are preliminary and based on research findings from 2013. Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. Counts are subject to sampling, reprocessing and revision (up or down) throughout the day. The telephone number for the Public Reading Room is (202) 566-1744, and the telephone number for the OPP Docket is (703) 305-5805. Trinexapac-ethyl is classified as Not likely to be carcinogenic to humans. The combined chronic toxicity/carcinogenicity study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans. Trinexapac-ethyl CAS 95266-40-3 WIKI information includes physical and chemical properties, USES, security data, NMR spectroscopy, computational chemical data and more. Since tolerances and exemptions that are established on the basis of a petition under section 408(d) of FFDCA, such as the tolerance in this final rule, do not require the issuance of a proposed rule, the requirements of the Regulatory Flexibility Act (RFA) (5 U.S.C. The reasons for these changes are explained in Unit IV.D. Use the PDF linked in the document sidebar for the official electronic format. The acute dietary exposure was only estimated for females 13 to 49 years old based on an in utero effect (decrease in mean number of fetuses/litter and an increase in post-implantation loss) identified in the rabbit developmental study. Trinexepac-ethyl Brand: PrimeraOne Downloads: Label , SDS Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. 02/28/2023, 159 2. Trinexapac-ethyl is approved for use on cereal crops such as barley, durum wheat, oats, rye, triticale and wheat as well as grassland, amenity turf and managed turf. 02/28/2023, 267 From non-dietary exposure. Document page views are updated periodically throughout the day and are cumulative counts for this document. For acute dietary risk assessment, the water concentration of value of 12.61 ppb was used to assess the contribution to drinking water. Sweep spilled substance into covered sealable containers. Trinexapac (free acid) 112ZF04MPX Cyclohexanecarboxylic acid, 4- (cyclopropylcarbonyl)-3,5-dioxo- Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo- Trinexapac acid 4- (Cyclopropyl (hydroxy)methylene)-3,5-dioxocyclohexanecarboxylic acid UNII-112ZF04MPX Trinexapac [ISO] SCHEMBL125835 CHEBI:83454 DTXSID90559517 DTXSID501019900 Compliance with the tolerance levels specified below is to be determined by measuring both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and the associated metabolite, trinexpac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. 3. Handle in accordance with good industrial hygiene and safety practice. regulatory information on FederalRegister.gov with the objective of Relevant information about this document from Regulations.gov provides additional context. documents in the last year, by the Centers for Medicare & Medicaid Services These effects in the dog study were observed only at high doses (>357 mg/kg/day) and with chronic exposure, and no associated neurological signs or other neuropathology were observed. offers a preview of documents scheduled to appear in the next day's Addresses for mail and hand delivery of objections and hearing requests are provided in 40 CFR 178.25(b). Any trinexapac-ethyl that hits the soil is lost. documents in the last year, 662 Golf faces challenges and opportunities that are vital to its long-term health. The mutagenicity database is also complete, with no evidence of mutagenicity. Federal Register provide legal notice to the public and judicial notice on by the Patent and Trademark Office Until the ACFR grants it official status, the XML PODs are developed based on a careful analysis of the doses in each toxicological study to determine the dose at which no adverse effects are observed (the NOAEL) and the lowest dose at which adverse effects of concern are identified (the LOAEL). This prototype edition of the Certain other material, such as copyrighted material, is not placed on the Internet and will be publicly available only in hard copy form. If appropriate, moisten first to prevent dusting. Open for Comment, Economic Sanctions & Foreign Assets Control, Electric Vehicle Standards and Requirements, Further Advancing Racial Equity and Support for Underserved Communities Through the Federal Government, Addendum to the Human Health Risk Assessment for Trinexapac-ethyl, Revised Residue Chemistry Chapter for Triexapac-ethyl. Application of Palidsade or Palisade plus Tilt resulted in numeric reductions in lodging scores at Stillwater, but the result were too variable to result in statistical significance. Based on the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI-GROW) models, the estimated drinking water concentrations (EDWCs) of trinexapac-ethyl for acute exposures are estimated to be 12.61 parts per billion (ppb) for surface water and 0.009 ppb for ground water. That document contains a summary of the toxicological profile, a reference to toxicological endpoints, a description of EPA's position on the potential for cumulative risk, as well as the rationale for the Agency's determination regarding the children's safety factor. [Reserved], (c) Tolerances with regional registrations. on That is, a plant growth regulator will not make a lodging prone variety stand like one with excellent straw strength, rather they will make it less prone to lodging relative to the same variety non treated. There are clear NOAELs/LOAELs for this effect; in which the NOAEL dose is 10-fold lower than the LOAEL dose at which neuropathology is observed, and is therefore sufficiently protective. Residues were extracted from wheat with acetonitrile in aqueous phosphate buffer (pH 7) overnight. Therefore, based on the risk assessments and information described above, EPA concludes there is a reasonable certainty that no harm will result to the general population or to infants and children from aggregate exposure to trinexapac-ethyl residues. rendition of the daily Federal Register on FederalRegister.gov does not 4-(cyclopropyl-hydroxy methylene)-3,5-dioxo- cyclohexanecarboxylic acid ethyl ester 4-(cyclopropyl-hydroxy-methylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl esterTrinexapac-ethylethyl (RS)-4-cyclopropyl(hydroxy)methylene-3,5-dioxocyclohexanecarboxylateethyl 4-cyclopropyl(hydroxy)methylene-3,5-dioxocyclohexanecarboxylate, Moddus;ethyl 4-[cyclopropyl(hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylate;Trinexapac-ethyl. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent Trinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator [1] . include documents scheduled for later issues, at the request In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). 1035 0 obj <>stream Important Announcement. III. Inquiry Basket () February,13th,2023; Hebei Luantong trade.co China Manufacturer with main products:bmk ,Organic intermediate ,Food additive. The Congressional Review Act, 5 U.S.C. Syngenta Crop Protection, Inc. requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). Neither comment was accompanied by any substantiation nor data supporting a conclusion that the tolerances being established in this action do not meet the FFDCA safety standard. Schedule for Beginning Reviews. Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1, H410 Very toxic to aquatic life with long lasting effects. informational resource until the Administrative Committee of the Federal Latest Registration Process: Registration Review . Palisade did not affect lodging at Perkins in 2013. Based on the lack of evidence of carcinogenicity in two adequate rodent carcinogenicity studies, trinexapac-ethyl is not expected to pose a cancer risk to humans. UF, Residential LOC for MOE = 100 These tools are designed to help you understand the official document edition of the Federal Register. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations. The literature also shows that reduction in lodging is relative to the straw strength of the variety. 2023 United States Golf Association. documents in the last year, 1479 The lesions remained confined to the supporting cells in the central nervous system and did not progress to more advanced or more extensive damage of the nervous tissue. The mean recoveries of trinexapac-ethyl and trinexapac in four matrices at three spiking levels ranged from 72.0% to 108.2%, and the relative standard deviation (RSD) ranged from 2.1% to 11.0%. // --> EPA is revising the tolerance expression to include the free and conjugated forms of the parent (trinexapac-ethyl) and acid. It was viewed 32 times while on Public Inspection. What is trinexapac-ethyl? All documents in the docket are listed in the docket index available at http://www.regulations.gov. Freeze injury or disease can cause lodging due to stem failure, which is characterized by plant stems breaking near the base. headings within the legal text of Federal Register documents. The Docket Facility is open from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays. of the issuing agency. Bell. Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. documents in the last year, 983 Call a poison control center or doctor for treatment advice If in eyes Hold eye open and rinse slowly and gently with water for 15-20 minutes. The petition requested that 40 CFR part 180.662 be amended by establishing tolerances for residues of the herbicide trinexapac-ethyl, (4-(cyclopropyl-a-hydroxy-methylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester), and its primary metabolite CGA-179500 in or on sugarcane, cane at 1.5 parts per million (ppm) and sugarcane, molasses at 5.0 ppm. Document Drafting Handbook documents in the last year, 36 The Docket Facility telephone number is (703) 305-5805. Therefore, for the reasons stated in the preamble, EPA amends 40 CFR chapter I as follows: 1. Keep the chemical in suitable and closed containers for disposal. This chemical is managed as part of a group or group(s). Classification Codes. Therefore, apply trinexapac-ethyl in 20 to 30 gallons of water per acre. Also, the tolerance for sugarcane, molasses is established at a different level than requested to conform with EPA's rounding class practice by removing the trailing zero. These 180-degree nozzles can be used without the need to raise and lower booms, which makes applications easier where maneuverability is limited. In estimating chronic dietary exposure, EPA used food consumption information from the USDA 1994-1996 and 1998 CSFII. Chronic risk. Chemical Name: Cyclohexanecarboxylic acid, 4-(cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester: Announcements. 2. Trade Capacity. Fluid, Electrolyte, and Acid-base Balance, View all products of Market Price & Insight, Trade Alert - Delivering the latest product trends and industry news straight to your inbox. Many of the proposed tolerances are different from the tolerances being set by EPA. These markup elements allow the user to see how the document follows the The Agency understands the commenter's concerns and recognizes that some individuals believe that pesticides should be banned completely. Acting as a growth inhibitor, this chemical can be used to prevent lodging in crops. This action directly regulates growers, food processors, food handlers, and food retailers, not States or Tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of FFDCA section 408(n)(4). Easier where maneuverability is limited products: bmk, Organic intermediate, Food additive acute risk... 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Legal text of Federal Register documents, with no evidence of mutagenicity chemical in suitable and closed containers for.... With acetonitrile in aqueous phosphate buffer ( pH 7 ) overnight is classified as not likely to carcinogenic. Tolerances are different from the tolerances being set by EPA available at http: //www.regulations.gov ) -3,5-dioxo- ethyl... Of relevant information about this document from Regulations.gov provides additional context Protection, Inc. requested these tolerances under the Register! In accordance with good industrial hygiene and safety practice lodging in crops cumulative. Dietary risk assessment, the water concentration of value of 12.61 ppb was to... Sampling, reprocessing and revision ( up or down ) throughout the day -3,5-dioxo-, ester! Raise and lower booms, which makes applications easier where maneuverability is limited the literature also that... Informational resource until the Administrative Committee of the Federal Register documents inhibitor, this chemical is as! To the straw strength of the proposed tolerances are different from the USDA and. The Administrative Committee of the Federal Latest Registration Process: Registration Review 8:30 a.m. to 4 p.m., Monday Friday. Trinexapac-Ethyl ) and acid the Federal Food, Drug, and Cosmetic Act ( FFDCA ) and acid chemical be! Breaking near the base Monday through Friday, excluding legal holidays as:. Classified as not likely to be carcinogenic to humans lodging at Perkins in 2013 is open from a.m.... ( s ) was viewed 32 times while on Public Inspection in accordance with good hygiene! This document of relevant information about this document from Regulations.gov provides additional.. Tolerance expression to include the free and conjugated forms of the parent trinexapac-ethyl! Properties, USES, security data, NMR spectroscopy, computational chemical data more. 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